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Contribution of p53 to metastasis
The tumor suppressor p53 is lost or mutated in about half of all human cancers and in those tumors where it is wild-type, mechanisms exist to prevent its activation. p53 loss not only prevents incipient tumor cells from undergoing oncogene-induced senescence and apoptosis but also perturbs cell cycl...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4063123/ https://ncbi.nlm.nih.gov/pubmed/24658082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0136 |
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