Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Cell cycle regulation in hematopoietic stem cells (HSCs) is tightly controlled during homeostasis and in response to extrinsic stress. p53, a well-known tumor suppressor and transducer of diverse stress signals, has been implicated in maintaining HSC quiescence and self-renewal. However, the mechani...

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Detalhes bibliográficos
Main Authors: Wang, Yunyuan V., Leblanc, Mathias, Fox, Norma, Mao, Jian-Hua, Tinkum, Kelsey L., Krummel, Kurt, Engle, Dannielle, Piwnica-Worms, David, Piwnica-Worms, Helen, Balmain, Allan, Kaushansky, Kenneth, Wahl, Geoffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134085/
https://ncbi.nlm.nih.gov/pubmed/21724834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2024411
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