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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
P53 is an unstable transcription factor that is mutated in a majority of human cancers. With a significant role in initiating cell elimination programs, a network has evolved to fine-tune P53 transcriptional output and prevent errant activation. Modifications of the C terminus have long been viewed...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1177381/ https://ncbi.nlm.nih.gov/pubmed/16006521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503068102 |
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