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Mouse Mutants Reveal that Putative Protein Interaction Sites in the p53 Proline-Rich Domain Are Dispensable for Tumor Suppression
The stability and activity of tumor suppressor p53 are tightly regulated and partially depend on the p53 proline-rich domain (PRD). We recently analyzed mice expressing p53 with a deletion of the PRD (p53(ΔP)). p53(ΔP), a weak transactivator hypersensitive to Mdm2-mediated degradation, is unable to...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800716/ https://ncbi.nlm.nih.gov/pubmed/17158931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00999-06 |
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