Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected. The polyQ expansion that causes Huntington's disease (HD) is in the first exon (HDx-1) of huntingtin (Htt). However,...

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Detalhes bibliográficos
Main Authors: Southwell, Amber L., Khoshnan, Ali, Dunn, Denise E., Bugg, Charles W., Lo, Donald C., Patterson, Paul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633448/
https://ncbi.nlm.nih.gov/pubmed/18768695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2747-08.2008
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