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Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected. The polyQ expansion that causes Huntington's disease (HD) is in the first exon (HDx-1) of huntingtin (Htt). However,...

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Bibliografiske detaljer
Main Authors: Southwell, Amber L., Khoshnan, Ali, Dunn, Denise E., Bugg, Charles W., Lo, Donald C., Patterson, Paul H.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633448/
https://ncbi.nlm.nih.gov/pubmed/18768695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2747-08.2008
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