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The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage
In addition to promoting cell death and senescence, p53 also has important cellular survival functions. A mutant p53, lacking a proline-rich domain (p53(ΔP)), that is deficient in controlling both cell death and cell cycle arrest, was employed to determine the biological means by which p53 mediates...
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| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635218/ https://ncbi.nlm.nih.gov/pubmed/28753207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.116 |
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