Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

All cells are unavoidably exposed to chemicals that can alkylate DNA to form genotoxic damage. Among the various DNA lesions formed, O(6)-alkylguanine lesions can be highly cytotoxic, and we recently demonstrated that O(6)-methylguanine (O(6)MeG) and O(6)-chloroethylguanine (O(6)CEG) specifically in...

Full description

Saved in:
Bibliographic Details
Main Authors: Hickman, Mark J., Samson, Leona D.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17957/
https://ncbi.nlm.nih.gov/pubmed/10485900
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items