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Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response
BACKGROUND: Mediating DNA damage-induced apoptosis is an important genome-maintenance function of the mismatch repair (MMR) system. Defects in MMR not only cause carcinogenesis, but also render cancer cells highly resistant to chemotherapeutics, including alkylating agents. To understand the mechani...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848634/ https://ncbi.nlm.nih.gov/pubmed/24330662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-3-37 |
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