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SERIES: Genomic instability in cancer Balancing repair and tolerance of DNA damage caused by alkylating agents
Alkylating agents comprise a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER), and mismatch repair (...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586545/ https://ncbi.nlm.nih.gov/pubmed/22237395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3185 |
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