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Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos
S(N)1-type alkylating agents, like N-methyl-N-nitrosourea (MNU) and N-ethyl-N-nitrosourea (ENU), are potent mutagens. Exposure to alkylating agents gives rise to O(6)-alkylguanine, a modified base that is recognized by DNA mismatch repair (MMR) proteins but is not repairable, resulting in replicatio...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475609/ https://ncbi.nlm.nih.gov/pubmed/18522974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn341 |
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