Sperm DNA damage causes genomic instability in early embryonic development

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiatio...

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Udgivet i:Sci Adv
Main Authors: Middelkamp, Sjors, van Tol, Helena T. A., Spierings, Diana C. J., Boymans, Sander, Guryev, Victor, Roelen, Bernard A. J., Lansdorp, Peter M., Cuppen, Edwin, Kuijk, Ewart W.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159919/
https://ncbi.nlm.nih.gov/pubmed/32494621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz7602
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