Early divergence of mutational processes in human fetal tissues

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were ab...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Kuijk, Ewart, Blokzijl, Francis, Jager, Myrthe, Besselink, Nicolle, Boymans, Sander, Chuva de Sousa Lopes, Susana M., van Boxtel, Ruben, Cuppen, Edwin
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2019
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541467/
https://ncbi.nlm.nih.gov/pubmed/31149636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw1271
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