Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and accelerate aging. Mutational characteristics of NER-deficiency may reveal important diagnostic opportunities,...

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Vydáno v:Genome Res
Hlavní autoři: Jager, Myrthe, Blokzijl, Francis, Kuijk, Ewart, Bertl, Johanna, Vougioukalaki, Maria, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, de Ligt, Joep, Pedersen, Jakob Skou, Hoeijmakers, Jan, Pothof, Joris, van Boxtel, Ruben, Cuppen, Edwin
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633256/
https://ncbi.nlm.nih.gov/pubmed/31221724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.246223.118
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