5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide synthesis and incorporates into DNA, which may have a mutational impact on both surviving tumor and healthy cells. Here, we treat intestinal organoid...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Christensen, Sharon, Van der Roest, Bastiaan, Besselink, Nicolle, Janssen, Roel, Boymans, Sander, Martens, John W. M., Yaspo, Marie-Laure, Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin, Van Hoeck, Arne
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783534/
https://ncbi.nlm.nih.gov/pubmed/31594944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12594-8
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