The mutational impact of culturing human pluripotent and adult stem cells

Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual human stem cells by whole genome sequencing. Individual pluripotent, intesti...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237696/
https://ncbi.nlm.nih.gov/pubmed/32427826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16323-4
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