Lack of Major Genome Instability in Tumors of p53 Null Rats

Tumorigenesis is often associated with loss of tumor suppressor genes (such as TP53), genomic instability and telomere lengthening. Previously, we generated and characterized a rat p53 knockout model in which the homozygous rats predominantly develop hemangiosarcomas whereas the heterozygous rats ma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, Simonis, Marieke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374866/
https://ncbi.nlm.nih.gov/pubmed/25811670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122066
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