Chromosome instability contributes to loss of heterozygosity in mice lacking p53
The p53 tumor suppressor protein participates in multiple cellular processes including cell cycle checkpoints and programmed cell death. In cell lines, loss of p53 function is associated with increased genetic instability including aneuploidy, gene amplification, and point mutation. Although similar...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16558/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10861008/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.13.7405 |
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