Chromosome instability contributes to loss of heterozygosity in mice lacking p53

The p53 tumor suppressor protein participates in multiple cellular processes including cell cycle checkpoints and programmed cell death. In cell lines, loss of p53 function is associated with increased genetic instability including aneuploidy, gene amplification, and point mutation. Although similar...

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Hauptverfasser: Shao, Changshun, Deng, Li, Henegariu, Octavian, Liang, Li, Stambrook, Peter J., Tischfield, Jay A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16558/
https://ncbi.nlm.nih.gov/pubmed/10861008
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