Homozygous and Heterozygous p53 Knockout Rats Develop Metastasizing Sarcomas with High Frequency

The TP53 tumor suppressor gene is mutated in the majority of human cancers. Inactivation of p53 in a variety of animal models results in early-onset tumorigenesis, reflecting the importance of p53 as a gatekeeper tumor suppressor. We generated a mutant Tp53 allele in the rat using a target-selected...

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Bibliografiske detaljer
Main Authors: van Boxtel, Ruben, Kuiper, Raoul V., Toonen, Pim W., van Heesch, Sebastiaan, Hermsen, Roel, de Bruin, Alain, Cuppen, Edwin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181367/
https://ncbi.nlm.nih.gov/pubmed/21854749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.036
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