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Direct Repair of 3,N(4)-Ethenocytosine by the Human ALKBH2 Dioxygenase is blocked by the AAG/MPG Glycosylase
Exocyclic ethenobases are highly mutagenic DNA lesions strongly implicated in inflammation and vinyl chloride-induced carcinogenesis. While the alkyladenine DNA glycosylase, AAG (or MPG), binds the etheno lesions 1,N(6)-ethenoadenine (εA) and 3,N(4)-ethenocytosine (εC) with high affinity, only εA ca...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253959/ https://ncbi.nlm.nih.gov/pubmed/22079122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.10.004 |
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