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Direct Repair of 3,N(4)-Ethenocytosine by the Human ALKBH2 Dioxygenase is blocked by the AAG/MPG Glycosylase

Exocyclic ethenobases are highly mutagenic DNA lesions strongly implicated in inflammation and vinyl chloride-induced carcinogenesis. While the alkyladenine DNA glycosylase, AAG (or MPG), binds the etheno lesions 1,N(6)-ethenoadenine (εA) and 3,N(4)-ethenocytosine (εC) with high affinity, only εA ca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fu, Dragony, Samson, Leona D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253959/
https://ncbi.nlm.nih.gov/pubmed/22079122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.10.004
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