Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N(4)-Ethenocytosine-containing DNA

Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in chronically inflamed tissues, readily damage DNA, producing a variety of potentially genotoxic etheno base lesions; such inflammation-related DNA damage is now known to contribute to carcinogenesis. Although the human...

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Autores principales: Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Setser, Jeremy W., Samson, Leona D., Drennan, Catherine L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075667/
https://ncbi.nlm.nih.gov/pubmed/21349833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192435
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