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Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N(4)-Ethenocytosine-containing DNA
Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in chronically inflamed tissues, readily damage DNA, producing a variety of potentially genotoxic etheno base lesions; such inflammation-related DNA damage is now known to contribute to carcinogenesis. Although the human...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075667/ https://ncbi.nlm.nih.gov/pubmed/21349833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192435 |
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