Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase

Human alkyladenine DNA glycosylase (hAAG) excises alkylated purines, hypoxanthine and etheno bases from DNA to form abasic (AP) sites. Surprisingly, elevated expression of hAAG increases spontaneous frameshift mutagenesis. By random mutagenesis of eight active site residues, we isolated hAAG-Y127I/H...

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Main Authors: Klapacz, Joanna, Lingaraju, Gondichatnahalli M., Guo, Haiwei H., Shah, Dharini, Moar-Shoshani, Ayelet, Loeb, Lawrence A., Samson, Leona D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894629/
https://ncbi.nlm.nih.gov/pubmed/20347426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.038
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