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Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase
[Image: see text] To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions. Such a search can be facilitated by the ability of glycosylases, like AAG, to interact with DNA using two affinities: a...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2011
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254189/ https://ncbi.nlm.nih.gov/pubmed/22148158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201484k |
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