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The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants

Human AlkB homolog 2 (ALKBH2) is a DNA repair enzyme that catalyzes the direct reversal of DNA methylation damage through oxidative demethylation. While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, it remains unknown whether these two proteins alone form...

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Détails bibliographiques
Publié dans:DNA Repair (Amst)
Auteurs principaux: Fu, Dragony, Samson, Leona D., Hübscher, Ullrich, van Loon, Barbara
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206904/
https://ncbi.nlm.nih.gov/pubmed/26408825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.09.008
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