DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET) family enzymes, which are α-ketoglutarate (α-KG)...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bian, Ke, Lenz, Stefan A P, Tang, Qi, Chen, Fangyi, Qi, Rui, Jost, Marco, Drennan, Catherine L, Essigmann, John M, Wetmore, Stacey D, Li, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582317/
https://ncbi.nlm.nih.gov/pubmed/31114894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz395
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