Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the Tet proteins. Here we show that, in addition to 5hmC, the Tet proteins can generate 5-formylcytosine (...

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Hlavní autoři: Ito, Shinsuke, Shen, Li, Dai, Qing, Wu, Susan C., Collins, Leonard B., Swenberg, James A., He, Chuan, Zhang, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495246/
https://ncbi.nlm.nih.gov/pubmed/21778364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210597
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