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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the Tet proteins. Here we show that, in addition to 5hmC, the Tet proteins can generate 5-formylcytosine (...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3495246/ https://ncbi.nlm.nih.gov/pubmed/21778364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210597 |
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