The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage

In addition to promoting cell death and senescence, p53 also has important cellular survival functions. A mutant p53, lacking a proline-rich domain (p53(ΔP)), that is deficient in controlling both cell death and cell cycle arrest, was employed to determine the biological means by which p53 mediates...

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Publicat a:Cell Death Differ
Autors principals: Baran, Katherine, Yang, Mao, Dillon, Christopher P, Samson, Leona L, Green, Douglas R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635218/
https://ncbi.nlm.nih.gov/pubmed/28753207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.116
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