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MDM2 and MDM4: p53 regulators as targets in anticancer therapy
The gene TP53, encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. Importantly, p53 inactivation in cancers can also result from the amplification / overexpression of its specific inhibitors MDM2 and MDM4 (als...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2043116/ https://ncbi.nlm.nih.gov/pubmed/17499002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2007.03.022 |
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