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MDM2, MDMX and p53 in oncogenesis and cancer therapy

The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour suppressor. However, the MDM proteins modulate and respond to many other signalling networks in which they are embedded. Recent...

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Autores principales: Wade, Mark, Li, Yao-Cheng, Wahl, Geoffrey M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161369/
https://ncbi.nlm.nih.gov/pubmed/23303139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3430
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