p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

BACKGROUND: Despite advances in early diagnosis and treatment of cancer patients, metastasis remains the major cause of mortality. TP53 is one of the most frequently mutated genes in human cancer, and these alterations can occur during the early stages of oncogenesis or as later events as tumors pro...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Powell, Emily, Shao, Jiansu, Yuan, Yuan, Chen, Hsiang-Chun, Cai, Shirong, Echeverria, Gloria V., Mistry, Nipun, Decker, Keith F., Schlosberg, Christopher, Do, Kim-Anh, Edwards, John R., Liang, Han, Piwnica-Worms, David, Piwnica-Worms, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728775/
https://ncbi.nlm.nih.gov/pubmed/26818199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0673-9
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