p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

BACKGROUND: Despite advances in early diagnosis and treatment of cancer patients, metastasis remains the major cause of mortality. TP53 is one of the most frequently mutated genes in human cancer, and these alterations can occur during the early stages of oncogenesis or as later events as tumors pro...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Breast Cancer Res
Main Authors: Powell, Emily, Shao, Jiansu, Yuan, Yuan, Chen, Hsiang-Chun, Cai, Shirong, Echeverria, Gloria V., Mistry, Nipun, Decker, Keith F., Schlosberg, Christopher, Do, Kim-Anh, Edwards, John R., Liang, Han, Piwnica-Worms, David, Piwnica-Worms, Helen
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2016
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728775/
https://ncbi.nlm.nih.gov/pubmed/26818199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0673-9
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