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Cork-in-bottle mechanism of inhibitor binding to mammalian complex I
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic disorders, and various cancers. Several pharmacologically relevant but structur...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8121435/ https://ncbi.nlm.nih.gov/pubmed/33990335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4000 |
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