Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery

Por Johannessen, Cory M., Clemons, Paul A., Wagner, Bridget K.
Publicado no Trends Genet (2014)

Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

Por Sofer, Avi, Lei, Kui, Johannessen, Cory M., Ellisen, Leif W.
Publicado em 2005

The NF1 tumor suppressor critically regulates TSC2 and mTOR

Por Johannessen, Cory M., Reczek, Elizabeth E., James, Marianne F., Brems, Hilde, Legius, Eric, Cichowski, Karen
Publicado em 2005

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

Por Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
Publicado no PLoS One (2017)

A negative feedback signaling network underlies oncogene-induced senescence

Por Courtois-Cox, Stéphanie, Genther Williams, Sybil M., Reczek, Elizabeth E., Johnson, Bryan W., McGillicuddy, Lauren T., Johannessen, Cory M., Hollstein, Pablo, MacCollin, Mia, Cichowski, Karen
Publicado em 2006

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Por Johannessen, Cory M., Johnson, Laura A., Piccioni, Federica, Townes, Aisha, Frederick, Dennie T., Donahue, Melanie K., Narayan, Rajiv, Flaherty, Keith T., Wargo, Jennifer A., Root, David E., Garraway, Levi A.
Publicado em 2013

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma

Por Wood, Kris C., Konieczkowski, David J., Johannessen, Cory M., Boehm, Jesse S., Tamayo, Pablo, Botvinnik, Olga B., Mesirov, Jill P., Hahn, William C., Root, David E., Garraway, Levi A., Sabatini, David M.
Publicado em 2012

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

Por Wagle, Nikhil, Emery, Caroline, Berger, Michael F., Davis, Matthew J., Sawyer, Allison, Pochanard, Panisa, Kehoe, Sarah M., Johannessen, Cory M., MacConaill, Laura E., Hahn, William C., Meyerson, Matthew, Garraway, Levi A.
Publicado em 2011

Phenotypic characterization of a comprehensive set of MAPK1/ERK2 missense mutants

Por Brenan, Lisa, Andreev, Aleksandr, Cohen, Ofir, Pantel, Sasha, Kamburov, Atanas, Cacchiarelli, Davide, Persky, Nicole S., Zhu, Cong, Bagul, Mukta, Goetz, Eva M., Burgin, Alex B., Garraway, Levi A., Getz, Gad, Mikkelsen, Tarjei S., Piccioni, Federica, Root, David E., Johannessen, Cory M.
Publicado no Cell Rep (2016)

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

Por Konieczkowski, David J., Johannessen, Cory M., Abudayyeh, Omar, Kim, Jong Wook, Cooper, Zachary A., Piris, Adriano, Frederick, Dennie T., Barzily-Rokni, Michal, Straussman, Ravid, Haq, Rizwan, Fisher, David E., Mesirov, Jill P., Hahn, William C., Flaherty, Keith T., Wargo, Jennifer A., Tamayo, Pablo, Garraway, Levi A.
Publicado em 2014

A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer

Por Wilson, Frederick H., Johannessen, Cory M., Piccioni, Federica, Tamayo, Pablo, Kim, Jong Wook, Van Allen, Eliezer M., Corsello, Steven M., Capelletti, Marzia, Calles, Antonio, Butaney, Mohit, Sharifnia, Tanaz, Gabriel, Stacey B., Mesirov, Jill P., Hahn, William C., Engelman, Jeffrey A., Meyerson, Matthew, Root, David E., Jänne, Pasi A., Garraway, Levi A.
Publicado no Cancer Cell (2015)

A public genome-scale lentiviral expression library of human ORFs

Por Yang, Xiaoping, Boehm, Jesse S, Yang, Xinping, Salehi-Ashtiani, Kourosh, Hao, Tong, Shen, Yun, Lubonja, Rakela, Thomas, Sapana R, Alkan, Ozan, Bhimdi, Tashfeen, Green, Thomas M, Johannessen, Cory M, Silver, Serena, Nguyen, Cindy, Murray, Ryan R., Hieronymus, Haley, Balcha, Dawit, Fan, Changyu, Lin, Chenwei, Ghamsari, Lila, Vidal, Marc, Hahn, William C, Hill, David E, Root, David E
Publicado em 2011

MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition

Por Wagle, Nikhil, Van Allen, Eliezer M., Treacy, Daniel J., Frederick, Dennie T., Cooper, Zachary A., Taylor-Weiner, Amaro, Rosenberg, Mara, Goetz, Eva M., Sullivan, Ryan J., Farlow, Deborah N., Friedrich, Dennis C., Anderka, Kristin, Perrin, Danielle, Johannessen, Cory M., McKenna, Aaron, Cibulskis, Kristian, Kryukov, Gregory, Hodis, Eran, Lawrence, Donald P., Fisher, Sheila, Getz, Gad, Gabriel, Stacey B., Carter, Scott L., Flaherty, Keith T., Wargo, Jennifer A., Garraway, Levi A.
Publicado em 2013

COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation

Por Johannessen, Cory M., Boehm, Jesse S., Kim, So Young, Thomas, Sapana R., Wardwell, Leslie, Johnson, Laura A., Emery, Caroline M., Stransky, Nicolas, Cogdill, Alexandria P., Barretina, Jordi, Caponigro, Giordano, Hieronymus, Haley, Murray, Ryan R., Salehi-Ashtiani, Kourosh, Hill, David E., Vidal, Marc, Zhao, Jean J., Yang, Xiaoping, Alkan, Ozan, Kim, Sungjoon, Harris, Jennifer L., Wilson, Christopher J., Myer, Vic E., Finan, Peter M., Root, David E., Roberts, Thomas M., Golub, Todd, Flaherty, Keith T., Dummer, Reinhard, Weber, Barbara, Sellers, William R., Schlegel, Robert, Wargo, Jennifer A., Hahn, William C., Garraway, Levi A.
Publicado em 2010

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Por Tirosh, Itay, Izar, Benjamin, Prakadan, Sanjay M., Wadsworth, Marc H., Treacy, Daniel, Trombetta, John J., Rotem, Asaf, Rodman, Christopher, Lian, Christine, Murphy, George, Fallahi-Sichani, Mohammad, Dutton-Regester, Ken, Lin, Jia-Ren, Cohen, Ofir, Shah, Parin, Lu, Diana, Genshaft, Alex S., Hughes, Travis K., Ziegler, Carly G. K., Kazer, Samuel W., Gaillard, Aleth, Kolb, Kellie E., Villani, Alexandra-Chloé, Johannessen, Cory M., Andreev, Aleksandr Y., Van Allen, Eliezer M., Bertagnolli, Monica, Sorger, Peter K., Sullivan, Ryan J., Flaherty, Keith T., Frederick, Dennie T., Jané-Valbuena, Judit, Yoon, Charles H., Rozenblatt-Rosen, Orit, Shalek, Alex K., Regev, Aviv, Garraway, Levi A.
Publicado no Science (2016)

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Por Adalsteinsson, Viktor A., Ha, Gavin, Freeman, Samuel S., Choudhury, Atish D., Stover, Daniel G., Parsons, Heather A., Gydush, Gregory, Reed, Sarah C., Rotem, Denisse, Rhoades, Justin, Loginov, Denis, Livitz, Dimitri, Rosebrock, Daniel, Leshchiner, Ignaty, Kim, Jaegil, Stewart, Chip, Rosenberg, Mara, Francis, Joshua M., Zhang, Cheng-Zhong, Cohen, Ofir, Oh, Coyin, Ding, Huiming, Polak, Paz, Lloyd, Max, Mahmud, Sairah, Helvie, Karla, Merrill, Margaret S., Santiago, Rebecca A., O’Connor, Edward P., Jeong, Seong H., Leeson, Rachel, Barry, Rachel M., Kramkowski, Joseph F., Zhang, Zhenwei, Polacek, Laura, Lohr, Jens G., Schleicher, Molly, Lipscomb, Emily, Saltzman, Andrea, Oliver, Nelly M., Marini, Lori, Waks, Adrienne G., Harshman, Lauren C., Tolaney, Sara M., Van Allen, Eliezer M., Winer, Eric P., Lin, Nancy U., Nakabayashi, Mari, Taplin, Mary-Ellen, Johannessen, Cory M., Garraway, Levi A., Golub, Todd R., Boehm, Jesse S., Wagle, Nikhil, Getz, Gad, Love, J. Christopher, Meyerson, Matthew
Publicado no Nat Commun (2017)