Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

A detailed understanding of the mechanisms by which tumors acquire resistance to targeted anticancer agents should speed the development of treatment strategies with lasting clinical efficacy. RAF inhibition in BRAF-mutant melanoma exemplifies the promise and challenge of many targeted drugs; althou...

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Detalhes bibliográficos
Main Authors: Wagle, Nikhil, Emery, Caroline, Berger, Michael F., Davis, Matthew J., Sawyer, Allison, Pochanard, Panisa, Kehoe, Sarah M., Johannessen, Cory M., MacConaill, Laura E., Hahn, William C., Meyerson, Matthew, Garraway, Levi A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Biology of Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157968/
https://ncbi.nlm.nih.gov/pubmed/21383288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.33.2312
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