CyDNA: Synthesis and Replication of Highly Cy-Dye Substituted DNA by an Evolved Polymerase

por Ramsay, Nicola, Jemth, Ann-Sofie, Brown, Anthony, Crampton, Neal, Dear, Paul, Holliger, Philipp
Publicado em 2010

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA

por Loseva, Olga, Jemth, Ann-Sofie, Bryant, Helen E., Schüler, Herwig, Lehtiö, Lari, Karlberg, Tobias, Helleday, Thomas
Publicado em 2010

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

por Loseva, Olga, Jemth, Ann-Sofie, Bryant, Helen E., Schüler, Herwig, Lehtiö, Lari, Karlberg, Tobias, Helleday, Thomas
Publicado em 2012

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

por Škerlová, Jana, Unterlass, Judith, Göttmann, Mona, Marttila, Petra, Homan, Evert, Helleday, Thomas, Jemth, Ann-Sofie, Stenmark, Pål
Publicado no J Biol Chem (2020)

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

por Scaletti, Emma Rose, Vallin, Karl S., Bräutigam, Lars, Sarno, Antonio, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Jemth, Ann-Sofie
Publicado no J Biol Chem (2020)

Production, Purification, and Characterization of (15)N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements

por Reddy, Prasad T., Jaruga, Pawel, Nelson, Bryant C., Lowenthal, Mark S., Jemth, Ann-Sofie, Loseva, Olga, Coskun, Erdem, Helleday, Thomas, Dizdaroglu, Miral
Publicado no Methods Enzymol (2015)

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

por Bryant, Helen E, Petermann, Eva, Schultz, Niklas, Jemth, Ann-Sofie, Loseva, Olga, Issaeva, Natalia, Johansson, Fredrik, Fernandez, Serena, McGlynn, Peter, Helleday, Thomas
Publicado em 2009

Processing of protein ADP-ribosylation by Nudix hydrolases

por Palazzo, Luca, Thomas, Benjamin, Jemth, Ann-Sofie, Colby, Thomas, Leidecker, Orsolya, Feijs, Karla, Zaja, Roko, Loseva, Olga, Puigvert, Jordi Carreras, Matic, Ivan, Helleday, Thomas, Ahel, Ivan
Publicado no Biochem J (2015)

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

por Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas
Publicado no Nucleic Acids Res (2018)

NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine

por Valerie, Nicholas C.K., Hagenkort, Anna, Page, Brent D.G., Masuyer, Geoffrey, Rehling, Daniel, Carter, Megan, Bevc, Luka, Herr, Patrick, Homan, Evert, Sheppard, Nina G., Stenmark, Pål, Jemth, Ann-Sofie, Helleday, Thomas
Publicado no Cancer Res (2016)

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

por Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Publicado no Nat Commun (2015)

dUTPase inhibition augments replication defects of 5-Fluorouracil

por Hagenkort, Anna, Paulin, Cynthia B.J., Desroses, Matthieu, Sarno, Antonio, Wiita, Elisée, Mortusewicz, Oliver, Koolmeister, Tobias, Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Homan, Evert, Lundbäck, Thomas, Gustavsson, Anna-Lena, Scobie, Martin, Helleday, Thomas
Publicado no Oncotarget (2017)

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

por Rehling, Daniel, Zhang, Si Min, Jemth, Ann-Sofie, Koolmeister, Tobias, Throup, Adam, Wallner, Olov, Scaletti, Emma, Moriyama, Takaya, Nishii, Rina, Davies, Jonathan, Desroses, Matthieu, Rudd, Sean G., Scobie, Martin, Homan, Evert, Berglund, Ulrika Warpman, Yang, Jun J., Helleday, Thomas, Stenmark, Pål
Publicado no J Biol Chem (2021)

Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy

por Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Gokturk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna, Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio
Publicado em 2014

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

por Tampere, Marianna, Pettke, Aleksandra, Salata, Cristiano, Wallner, Olov, Koolmeister, Tobias, Cazares-Körner, Armando, Visnes, Torkild, Hesselman, Maria Carmen, Kunold, Elena, Wiita, Elisee, Kalderén, Christina, Lightowler, Molly, Jemth, Ann-Sofie, Lehtiö, Janne, Rosenquist, Åsa, Warpman-Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Jafari, Rozbeh, Puumalainen, Marjo-Riitta
Publicado no Viruses (2020)

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

por Carreras-Puigvert, Jordi, Zitnik, Marinka, Jemth, Ann-Sofie, Carter, Megan, Unterlass, Judith E., Hallström, Björn, Loseva, Olga, Karem, Zhir, Calderón-Montaño, José Manuel, Lindskog, Cecilia, Edqvist, Per-Henrik, Matuszewski, Damian J., Ait Blal, Hammou, Berntsson, Ronnie P. A., Häggblad, Maria, Martens, Ulf, Studham, Matthew, Lundgren, Bo, Wählby, Carolina, Sonnhammer, Erik L. L., Lundberg, Emma, Stenmark, Pål, Zupan, Blaz, Helleday, Thomas
Publicado no Nat Commun (2017)

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado no Nat Commun (2018)

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

por Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Publicado no Nat Commun (2019)

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

por Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A., Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K., Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Morón, Estefanía Burgos, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Berglund, Ulrika Warpman, Scobie, Martin, Helleday, Thomas
Publicado no J Med Chem (2016)

Development of a chemical probe against NUDT15

por Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C.K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Publicado no Nat Chem Biol (2020)