Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Deregulated redox metabolism in cancer leads to oxidative damage to cellular components including deoxyribonucleoside triphosphates (dNTPs). Targeting dNTP pool sanitizing enzymes, such as MTH1, is a highly promising anticancer strategy. The MTH2 protein, known as NUDT15, is described as the second...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532830/
https://ncbi.nlm.nih.gov/pubmed/26238318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8871
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