Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Deregulated redox metabolism in cancer leads to oxidative damage to cellular components including deoxyribonucleoside triphosphates (dNTPs). Targeting dNTP pool sanitizing enzymes, such as MTH1, is a highly promising anticancer strategy. The MTH2 protein, known as NUDT15, is described as the second...

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發表在:Nat Commun
Main Authors: Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532830/
https://ncbi.nlm.nih.gov/pubmed/26238318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8871
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