MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient catalyst of O6-methyl-dGTP hydrolysis suggesting that MTH1 may also sanitize the n...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Scaletti, Emma Rose, Vallin, Karl S., Bräutigam, Lars, Sarno, Antonio, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Jemth, Ann-Sofie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152754/
https://ncbi.nlm.nih.gov/pubmed/32144205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012636
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