Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells

SAMHD1 is a dNTP hydrolase, whose activity is required for maintaining low dNTP concentrations in non-cycling T cells, dendritic cells, and macrophages. SAMHD1-dependent dNTP depletion is thought to impair retroviral replication in these cells, but the relationship between the dNTPase activity and r...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Zhonghua, Bhattacharya, Akash, Villacorta, Jessica, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Accelerated Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076810/
https://ncbi.nlm.nih.gov/pubmed/27566548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C116.751446
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