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Structural basis of cellular dNTP regulation by SAMHD1
The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in mammalian...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4205617/ https://ncbi.nlm.nih.gov/pubmed/25267621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412289111 |
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