GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

The HIV-1 restriction factor sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase. Here, we...

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Hlavní autoři: Hansen, Erik C., Seamon, Kyle J., Cravens, Shannen L., Stivers, James T.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020072/
https://ncbi.nlm.nih.gov/pubmed/24753578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401706111
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