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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
The HIV-1 restriction factor sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1) is a tetrameric protein that catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively depletes the dNTP substrates of HIV reverse transcriptase. Here, we...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4020072/ https://ncbi.nlm.nih.gov/pubmed/24753578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401706111 |
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