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Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1
SAMHD1 is a cellular dNTPase that restricts lentiviral infection presumably by lowering cellular dNTP levels to below a critical threshold required for reverse transcription; however, lowering cellular dNTP levels may not be the sole mechanism of restriction. In particular, an exonuclease activity o...
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| Publicado no: | Virology |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744553/ https://ncbi.nlm.nih.gov/pubmed/26655245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.11.022 |
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