The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that depletes cellular dNTPs in noncycling cells to promote genome stability and to inhibit retroviral and herpes viral replication. In addition to being substrates, cellular nucleotides also allosterically regulate SAMHD1 activi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Knecht, Kirsten M., Buzovetsky, Olga, Schneider, Constanze, Thomas, Dominique, Srikanth, Vishok, Kaderali, Lars, Tofoleanu, Florentina, Reiss, Krystle, Ferreirós, Nerea, Geisslinger, Gerd, Batista, Victor S., Ji, Xiaoyun, Cinatl, Jindrich, Keppler, Oliver T., Xiong, Yong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205433/
https://ncbi.nlm.nih.gov/pubmed/30305425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805593115
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