The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that depletes cellular dNTPs in noncycling cells to promote genome stability and to inhibit retroviral and herpes viral replication. In addition to being substrates, cellular nucleotides also allosterically regulate SAMHD1 activi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Knecht, Kirsten M., Buzovetsky, Olga, Schneider, Constanze, Thomas, Dominique, Srikanth, Vishok, Kaderali, Lars, Tofoleanu, Florentina, Reiss, Krystle, Ferreirós, Nerea, Geisslinger, Gerd, Batista, Victor S., Ji, Xiaoyun, Cinatl, Jindrich, Keppler, Oliver T., Xiong, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205433/
https://ncbi.nlm.nih.gov/pubmed/30305425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805593115
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