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Mechanism of Allosteric Activation of SAMHD1 by dGTP
SAMHD1, a deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase), plays a key role in human innate immunity. It inhibits infection of blood cells by retroviruses, including HIV, and prevents the development of the autoinflammatory Aicardi-Goutières syndrome (AGS). The inactive apo-SAMHD1 int...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3833828/ https://ncbi.nlm.nih.gov/pubmed/24141705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2692 |
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