Mechanism of Allosteric Activation of SAMHD1 by dGTP

SAMHD1, a deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase), plays a key role in human innate immunity. It inhibits infection of blood cells by retroviruses, including HIV, and prevents the development of the autoinflammatory Aicardi-Goutières syndrome (AGS). The inactive apo-SAMHD1 int...

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Main Authors: Ji, Xiaoyun, Wu, Ying, Yan, Junpeng, Mehrens, Jennifer, Yang, Haitao, DeLucia, Maria, Hao, Caili, Gronenborn, Angela M., Skowronski, Jacek, Ahn, Jinwoo, Xiong, Yong
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833828/
https://ncbi.nlm.nih.gov/pubmed/24141705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2692
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