Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response. In monocytes and their differentiated derivatives, as well as in quiescent cells, SAMHD1 strongly inhibits HIV-1 infection and, to a lesser extent, HIV-2 and simian immunodeficiency virus (SIV)...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yan, Junpeng, Kaur, Sarabpreet, DeLucia, Maria, Hao, Caili, Mehrens, Jennifer, Wang, Chuanping, Golczak, Marcin, Palczewski, Krzysztof, Gronenborn, Angela M., Ahn, Jinwoo, Skowronski, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624423/
https://ncbi.nlm.nih.gov/pubmed/23426366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443796
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge