Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response. In monocytes and their differentiated derivatives, as well as in quiescent cells, SAMHD1 strongly inhibits HIV-1 infection and, to a lesser extent, HIV-2 and simian immunodeficiency virus (SIV)...

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Main Authors: Yan, Junpeng, Kaur, Sarabpreet, DeLucia, Maria, Hao, Caili, Mehrens, Jennifer, Wang, Chuanping, Golczak, Marcin, Palczewski, Krzysztof, Gronenborn, Angela M., Ahn, Jinwoo, Skowronski, Jacek
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624423/
https://ncbi.nlm.nih.gov/pubmed/23426366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443796
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