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Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection
SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response. In monocytes and their differentiated derivatives, as well as in quiescent cells, SAMHD1 strongly inhibits HIV-1 infection and, to a lesser extent, HIV-2 and simian immunodeficiency virus (SIV)...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624423/ https://ncbi.nlm.nih.gov/pubmed/23426366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443796 |
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